THE JANG LAB AIMS TO PROVIDE FUNDAMENTAL INSIGHTS AND PRACTICAL SOLUTIONS IN THE FIELD OF SUPRAMOLECULAR BIOMATERIALS. We are aiming at engineering structural and functional properties of supramolecular biomaterials for target applications including synthetic cells, smart capsules, micro-reactors, antibacterial, and drug release coatings. The vision of our lab is to utilize soft matter assembly and recombinant technology for the creation of advanced biomaterials. From the deep understanding of the interactions between soft matters, including polymers, proteins, and colloids, we develop supramolecular biomaterials to present target microscopic structure, mechanical properties, and functionality. We also apply recombinant protein technology to rationally design functional building blocks. The supramolecular biomaterials developed from my research group target to mimic sophisticated functions and structures of living systems, inspired by nature.
SYNTHETIC CELL MODEL DEVELOPMENT BY ENGINEERING GLOBULAR PROTEIN VESICLES
The goal of this project is to create minimal synthetic cells with recombinantly engineered fusion proteins that can self-assemble into a vesicle - an essential structure of a cell. This project seeks to provide basic understanding on how functional recombinant fusion proteins can self-assemble into a vesicle in aqueous solution, what drives ordered phase separation of different proteins at membranes, and how we can engineer the functional properties of protein-assembled vesicles towards synthetic cells.
PHASE STUDY OF GLOBULAR PROTEIN-DIBLOCK COPOLYMER BLENDS
We seek to provide the fundamental understanding of the self-assembly of globular fusion proteins with synthetic diblock copolymers that exhibit complex interactions. We study the phase transition/separation behavior of the globular fusion proteins in a macromolecularly crowded solution and at interface/surface under diverse physical and chemical stimuli, mainly using scattering and microscopy techniques. This study enables us to create a new supramolecular nanostructure with functional globular proteins.
FUNCTIONAL NANOTHIN FILMS FOR CELL FATE CONTROL
We develop functional thin films and coatings to control cell fate at the surfaces. We precisely control surface structure, chemistry, and mechanical properties of polymeric thin films to achieve target functionality to tailor cellular adhesion, proliferation, and death. The functional thin films have a variety of biomedical applications, such as stem cell co-culture platforms, antibacterial coatings, and drug release patches. Particularly, bacterial adhesion on medical implants and devices leads to serious infectious diseases. To address the human health issues from the growing number of drug-resistant bacteria, we develop a new approach to create bioinspired, bactericidal surfaces that can physically combat initial adhesion of bacteria. This study encompasses nanofabrication and characterization methods of polymer surfaces and assessment of antibacterial performance, which is applicable to different polymeric materials used in a wide range of medical implants and devices.
The goal of this project is to create minimal synthetic cells with recombinantly engineered fusion proteins that can self-assemble into a vesicle - an essential structure of a cell. This project seeks to provide basic understanding on how functional recombinant fusion proteins can self-assemble into a vesicle in aqueous solution, what drives ordered phase separation of different proteins at membranes, and how we can engineer the functional properties of protein-assembled vesicles towards synthetic cells.
PHASE STUDY OF GLOBULAR PROTEIN-DIBLOCK COPOLYMER BLENDS
We seek to provide the fundamental understanding of the self-assembly of globular fusion proteins with synthetic diblock copolymers that exhibit complex interactions. We study the phase transition/separation behavior of the globular fusion proteins in a macromolecularly crowded solution and at interface/surface under diverse physical and chemical stimuli, mainly using scattering and microscopy techniques. This study enables us to create a new supramolecular nanostructure with functional globular proteins.
FUNCTIONAL NANOTHIN FILMS FOR CELL FATE CONTROL
We develop functional thin films and coatings to control cell fate at the surfaces. We precisely control surface structure, chemistry, and mechanical properties of polymeric thin films to achieve target functionality to tailor cellular adhesion, proliferation, and death. The functional thin films have a variety of biomedical applications, such as stem cell co-culture platforms, antibacterial coatings, and drug release patches. Particularly, bacterial adhesion on medical implants and devices leads to serious infectious diseases. To address the human health issues from the growing number of drug-resistant bacteria, we develop a new approach to create bioinspired, bactericidal surfaces that can physically combat initial adhesion of bacteria. This study encompasses nanofabrication and characterization methods of polymer surfaces and assessment of antibacterial performance, which is applicable to different polymeric materials used in a wide range of medical implants and devices.
